Pure Peptides Australia
ARA-290 โ Research Peptide | Pure Peptides Australia
ARA-290 โ Research Peptide | Pure Peptides Australia
Not for human, veterinary, diagnostic, or therapeutic use.
Neuroprotection research compound
ARA-290 (10mg): Cibinetide, the Innate Repair Receptor Peptide from Erythropoietin
ARA-290, cibinetide in pharmaceutical development, is an eleven-amino-acid peptide copied from the part of erythropoietin that sits outside its binding site for the classic EPO receptor. That region turned out to activate a separate receptor, the innate repair receptor (a complex of the EPO receptor and the beta-common receptor), which drives tissue protection and anti-inflammatory signalling without the red-cell production that limits EPO itself. It is the leading research compound for small-fibre neuropathy and neuropathic pain. Searched as ara-290 australia, ara 290 peptide, cibinetide australia, ara290 neuropathy and innate repair receptor.
Pure Peptides Australia holds ARA-290 in Sydney stock as a 10mg lyophilised vial, Janoshik tested before listing. Orders confirmed before 12pm AEST on a business day are dispatched the same day with tracked delivery Australia-wide.
- ARA-290
- ARA290
- Cibinetide
- Innate repair receptor agonist
- EPO helix B peptide
- pHBSP
EPO's protective half without the blood effect
Erythropoietin protects tissue from injury as well as making red cells, but the red-cell effect makes it unusable for protection research: haematocrit rises and clotting risk with it. ARA-290 solves that by copying only helix B of EPO, the surface that engages the innate repair receptor. It has no activity at the EPO receptor homodimer, so it does not touch haematocrit, and its half-life is only a few minutes, yet the receptor it triggers produces effects that last days. That combination, a brief signal with a long downstream response, is what makes it an unusual and heavily studied molecule.
Key research areas
Small-fibre neuropathy
Phase 2 trials in sarcoidosis-associated small-fibre neuropathy reported increased corneal nerve fibre density and reduced neuropathic symptoms (Dahan et al., Molecular Medicine 2013; Culver et al., Frontiers in Neurology 2017).
Diabetic neuropathy
Studied for nerve fibre regeneration and improved metabolic control in type 2 diabetes with neuropathy (Brines et al., Molecular Medicine 2015).
Neuropathic pain
Reduced pain behaviour in nerve-injury models through anti-inflammatory rather than opioid mechanisms.
Innate repair receptor
The receptor complex itself, its expression after injury and its downstream JAK2, PI3K and NF-kB effects.
Wound and tissue protection
Studied in kidney, heart and retinal injury models for the tissue-protective arm of EPO signalling.
Metabolic effects
Improved HbA1c and lipids reported alongside neuropathy endpoints in the diabetes trial.
How ARA-290 works
The innate repair receptor is only assembled on cells after injury or inflammation, which is why ARA-290 acts where tissue is damaged and not elsewhere. Binding it activates JAK2 and PI3K-Akt survival signalling, suppresses NF-kB-driven cytokine release and, in nerve tissue, supports regrowth of small unmyelinated fibres. The peptide clears from plasma in about two minutes, but the receptor's response continues for days, so research protocols use brief repeated administration rather than sustained exposure.
Specifications
| Compound | ARA-290 (cibinetide) |
| Also known as | ARA290, cibinetide, pHBSP, pyroglutamate helix B surface peptide, innate repair receptor agonist |
| CAS number | 1208243-50-8 |
| Molecular formula | C51H84N16O21 |
| Molecular weight | 1257.3 g/mol |
| Sequence | pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser (11 amino acids) |
| Half-life (published) | Approximately 2 minutes in plasma; receptor effects persist days |
| Category | Neurological research |
| Purity | โฅ99% HPLC, batch COA supplied (Janoshik Analytical) |
| Form | Lyophilised powder in a sealed sterile vial |
| Vial size | 10mg |
| Storage (lyophilised) | -20ยฐC, protect from light, avoid freeze-thaw |
| Storage (reconstituted) | 2 to 8ยฐC, use within 28 days |
| Reconstitution | Bacteriostatic water |
Pricing in Australia
$99.99 for 10mg, $10.00 per mg
The published trials used 4mg daily for 28 days, so a 10mg vial covers a short arm and three vials cover a full trial-length protocol.
Reconstitution
Wipe the stopper, add bacteriostatic water slowly down the inside wall, swirl gently until clear, never shake. Refrigerate at 2 to 8ยฐC and use within 28 days.
| Water added | Concentration | 2mg on a U-100 syringe | 4mg on a U-100 syringe |
| 1mL | 10mg/mL | 20 units | 40 units |
| 2mL | 5mg/mL | 40 units | 80 units |
The reconstitution calculator runs the maths for any target.
Quality and COA verification
Every batch is tested by Janoshik Analytical: HPLC purity, mass-spec identity against 1257 g/mol, heavy metals and endotoxin. The batch number on the label matches the certificate.
Sydney stock, tracked delivery
No international transit or customs queue. Orders cleared before 12pm AEST leave the same business day; Express Post reaches most metro addresses in one to three business days.
Frequently bought together
From $69.99. Nerve repair models alongside.
$89.99. Immune-modulation research.
10mL $29.99, 3mL $14.99. Required for reconstitution.
5 pack $15.99, 10 pack $19.99.
ARA-290 Australia FAQ
What is ARA-290?
An eleven-amino-acid peptide copied from helix B of erythropoietin. It activates the innate repair receptor for tissue protection and anti-inflammatory signalling without EPO's red-cell effect, and is studied mainly in small-fibre neuropathy and neuropathic pain.
Is ARA-290 the same as cibinetide?
Yes. ARA-290 is the research designation; cibinetide is the development name for the same molecule.
How does ARA-290 work?
It binds the innate repair receptor, a complex assembled on cells only after injury, activating JAK2 and PI3K survival signalling and suppressing NF-kB. It has no activity at the classic EPO receptor, so it does not raise haematocrit.
What does the research show?
Increased corneal nerve fibre density and reduced neuropathic symptoms in Phase 2 trials in sarcoidosis and diabetic small-fibre neuropathy, with improved HbA1c in the diabetes cohort, plus tissue protection in kidney, heart and retinal injury models.
Why is the half-life so short?
The peptide clears in about two minutes, but the receptor it triggers keeps signalling for days. Published protocols use brief daily administration for that reason.
Can I buy ARA-290 at Chemist Warehouse in Australia?
No. Cibinetide is not registered anywhere and research-grade ARA-290 is not a pharmacy product. It is available only as a research-grade lyophilised vial.
How do you reconstitute ARA-290?
Add bacteriostatic water slowly down the inside wall, swirl gently until clear, never shake, refrigerate at 2 to 8ยฐC and use within 28 days. 1mL gives 10mg/mL, so 4mg is 40 units.
Is ARA-290 available in Australia?
As a research compound, yes: Pure Peptides Australia holds the 10mg vial in Sydney with same-day dispatch. As a medicine, no. As of October 2026 it is not TGA approved.
Where can I buy ARA-290 in Australia?
From this page. Check out with card, PayID, Osko or bank transfer and the vial leaves Sydney the same business day when payment clears before 12pm AEST, tracked to any Australian address.
What does ARA-290 cost in Australia?
$99.99 for the 10mg vial, $10.00 per mg. No surcharge on PayID, Osko or bank transfer.
Is ARA-290 legal in Australia?
Pure Peptides Australia supplies it strictly for lawful in-vitro laboratory research. It is not approved by the TGA for human or veterinary use and is not sold as a medicine, supplement or therapeutic good. Purchasers are responsible for ensuring their use complies with applicable laws.
