Pure Peptides Australia
IGF-1LR3 1mg โ Research Peptide | Pure Peptides Australia
IGF-1LR3 1mg โ Research Peptide | Pure Peptides Australia
Not for human, veterinary, diagnostic, or therapeutic use.
Growth factor research compound
IGF-1 LR3 (1mg): Long R3 Insulin-Like Growth Factor-1 for Cell Growth Research
IGF-1 LR3 is a modified form of insulin-like growth factor-1 with an arginine substituted at position 3 and a 13-amino-acid extension on the N-terminus. Those changes stop it binding the IGF-binding proteins that normally sequester IGF-1 in circulation, so it stays free and active far longer than native IGF-1 and is around three times more potent in cell culture. It is the standard IGF-1 analogue in cell growth, muscle and proliferation research. Searched as igf-1 lr3 australia, igf1 lr3, long r3 igf-1, igf-1 lr3 1mg and igf lr3 peptide.
Pure Peptides Australia holds IGF-1 LR3 in Sydney stock as a 1mg lyophilised vial, Janoshik tested before listing. Orders confirmed before 12pm AEST on a business day are dispatched the same day with tracked delivery Australia-wide.
- IGF-1 LR3
- Long R3 IGF-1
- LR3-IGF-1
- IGF1 LR3
- Insulin-like growth factor-1 analogue
Why the modification matters
Native IGF-1 is over 95% bound to IGF-binding proteins in circulation, which buffers it and gives it a half-life of minutes when free. The R3 substitution removes binding-protein affinity and the N-terminal extension protects against clearance, extending the active half-life to around 20 to 30 hours. That is why LR3 is used in cell culture in place of native IGF-1: a small amount stays active across an experiment. It also dissolves poorly at neutral pH and aggregates, so it is supplied and reconstituted in acetic acid water, not bacteriostatic water.
Key research areas
Cell culture growth factor
The standard serum-free media supplement for cell proliferation and recombinant protein production, replacing insulin and native IGF-1.
Muscle hypertrophy and repair
Satellite cell activation, myoblast proliferation and muscle regeneration in animal models.
Insulin and glucose signalling
IGF-1 receptor and insulin receptor cross-talk, PI3K-Akt activation and glucose uptake.
Neuronal survival
IGF-1 signalling studied for neuron survival and neurite outgrowth in neurodegeneration models.
Binding protein biology
LR3 as the tool for separating IGF-1 receptor effects from IGFBP effects, since it bypasses the binding proteins.
Growth hormone axis
The downstream effector of GH; studied alongside the GH secretagogues to distinguish direct IGF-1 effects from GH effects.
Specifications
| Compound | IGF-1 LR3 (Long R3 IGF-1) |
| Also known as | LR3-IGF-1, Long R3 insulin-like growth factor-1, IGF1 LR3, IGF-1 long arg3 |
| CAS number | 946870-92-4 |
| Molecular formula | C400H625N111O115S9 |
| Molecular weight | 9111 g/mol |
| Structure | 83 amino acids: IGF-1 (70 aa) with Arg3 substitution and 13-aa N-terminal extension |
| Half-life (published) | 20 to 30 hours |
| Category | Growth hormone and growth factor research |
| Purity | โฅ99% HPLC, batch COA supplied (Janoshik Analytical) |
| Form | Lyophilised powder in a sealed sterile vial |
| Vial size | 1mg |
| Storage (lyophilised) | -20ยฐC, protect from light, avoid freeze-thaw |
| Storage (reconstituted) | 2 to 8ยฐC, use within 14 days, or freeze single-use aliquots |
| Reconstitution | Acetic acid water 0.6%, not bacteriostatic water |
Pricing in Australia
$139.99 for 1mg, used in micrograms
IGF-1 LR3 is active in the 20 to 100mcg range, so a 1mg vial is 10 to 50 draws. It is the one compound in the range that needs acetic acid water ($19.99) rather than bacteriostatic water.
Reconstitution
Wipe the stopper, add 0.6% acetic acid water slowly down the inside wall, let stand and tilt gently until clear, never shake. Refrigerate at 2 to 8ยฐC and use within 14 days, or freeze single-use aliquots. Dilute an aliquot into bacteriostatic water at the point of use if a neutral vehicle is needed.
| Acetic acid water added | Concentration | 20mcg on a U-100 syringe | 50mcg on a U-100 syringe |
| 1mL | 1mg/mL | 2 units | 5 units |
| 2mL | 500mcg/mL | 4 units | 10 units |
The reconstitution calculator runs the maths for any target.
Quality and COA verification
Every batch is tested by Janoshik Analytical: HPLC purity, mass-spec identity against 9111 g/mol, heavy metals and endotoxin. The batch number on the label matches the certificate.
Sydney stock, tracked delivery
No international transit or customs queue. Orders cleared before 12pm AEST leave the same business day; Express Post reaches most metro addresses in one to three business days.
Frequently bought together
$19.99. Required diluent.
$129.99. The GH-axis upstream of IGF-1.
From $69.99. Muscle repair models alongside.
5 pack $15.99, 10 pack $19.99.
IGF-1 LR3 Australia FAQ
What is IGF-1 LR3?
A modified insulin-like growth factor-1 with an Arg3 substitution and a 13-amino-acid N-terminal extension that stop it binding IGF-binding proteins. It stays active far longer than native IGF-1 and is the standard IGF-1 analogue in cell growth and muscle research.
IGF-1 LR3 vs IGF-1?
Native IGF-1 is mostly bound and inactive in circulation with a half-life of minutes when free. LR3 bypasses the binding proteins and lasts 20 to 30 hours, so it is roughly three times more potent in culture.
How does IGF-1 LR3 work?
It activates the IGF-1 receptor, driving PI3K-Akt and MAPK signalling for cell proliferation, protein synthesis and survival, and cross-activates the insulin receptor for glucose uptake.
Why acetic acid water?
IGF-1 LR3 aggregates and loses activity at neutral pH. 0.6% acetic acid keeps it in solution. Reconstitute in acetic acid water, then dilute into bacteriostatic water at the point of use if needed.
How do you reconstitute IGF-1 LR3?
Add 1mL of acetic acid water slowly down the inside wall, let stand until clear, never shake. That gives 1mg/mL, so 20mcg is 2 units. Refrigerate and use within 14 days, or freeze aliquots.
Can I buy IGF-1 LR3 at Chemist Warehouse in Australia?
No. IGF-1 LR3 is not a registered medicine and no Australian pharmacy stocks it. It is available only as a research-grade lyophilised vial.
Is IGF-1 LR3 available in Australia?
As a research compound, yes: Pure Peptides Australia holds the 1mg vial in Sydney with same-day dispatch. As a medicine, no. As of October 2026 it is not TGA approved.
Where can I buy IGF-1 LR3 in Australia?
From this page. Check out with card, PayID, Osko or bank transfer and the vial leaves Sydney the same business day when payment clears before 12pm AEST, tracked to any Australian address.
What does IGF-1 LR3 cost in Australia?
$139.99 for the 1mg vial. No surcharge on PayID, Osko or bank transfer.
Is IGF-1 LR3 legal in Australia?
Pure Peptides Australia supplies it strictly for lawful in-vitro laboratory research. It is not approved by the TGA for human or veterinary use and is not sold as a medicine, supplement or therapeutic good. Purchasers are responsible for ensuring their use complies with applicable laws.
