Pure Peptides Australia
Kisspeptin-10 10mg โ Research Peptide | Pure Peptides Australia
Kisspeptin-10 10mg โ Research Peptide | Pure Peptides Australia
Not for human, veterinary, diagnostic, or therapeutic use.
Reproductive research compound
Kisspeptin-10 (10mg): The Upstream Regulator of the Reproductive Axis
Kisspeptin-10 is the ten-amino-acid active fragment of the kisspeptin protein encoded by the KISS1 gene. It binds the KISS1 receptor (GPR54) on hypothalamic GnRH neurons and triggers the release of gonadotropin-releasing hormone, which drives LH and FSH from the pituitary. Its discovery in 2003 rewrote reproductive endocrinology: kisspeptin sits above GnRH, and every downstream sex hormone answers to it. Searched as kisspeptin australia, kisspeptin 10, kisspeptin peptide and kp-10.
Pure Peptides Australia holds Kisspeptin-10 in Sydney stock as a 10mg lyophilised vial, Janoshik tested before listing. Orders confirmed before 12pm AEST on a business day are dispatched the same day with tracked delivery Australia-wide.
- Kisspeptin-10
- KP-10
- Metastin 45-54
- KISS1 fragment
- GPR54 agonist
- Kisspeptin
Why it is studied
Before kisspeptin, GnRH was treated as the top of the reproductive axis. Loss-of-function mutations in GPR54 causing failed puberty (de Roux et al., PNAS 2003; Seminara et al., NEJM 2003) showed there was a layer above it. Kisspeptin-10 is the shortest fragment that fully activates the receptor, which makes it the reference tool for studying pulsatile gonadotropin release, puberty onset, hypothalamic amenorrhoea and the hormonal feedback loops that oestrogen and testosterone exert on the brain.
Key research areas
GnRH and LH release
Human studies (Dhillo et al., JCEM 2005) reported a rapid LH rise after kisspeptin, the founding observation for its use as a GnRH secretagogue.
Hypothalamic amenorrhoea
Studied for restoring LH pulsatility in women with suppressed reproductive function (Jayasena et al., JCEM 2009).
Oocyte maturation
Kisspeptin-54 studied as an ovulation trigger in IVF that avoids ovarian hyperstimulation (Abbara et al., JCEM 2015).
Male reproductive axis
Studied for testosterone response via LH in men, including hypogonadotropic models.
Puberty and feedback
The KNDy neuron model of GnRH pulse generation, where kisspeptin, neurokinin B and dynorphin coordinate the pulse.
Behaviour and mood
fMRI work (Comninos et al., JCI 2017) examined kisspeptin's effects on limbic activity and sexual and emotional processing.
How Kisspeptin-10 works
Binding GPR54 on GnRH neurons activates a Gq-coupled cascade that depolarises the neuron and releases GnRH into the portal circulation. The pituitary responds with LH and, more slowly, FSH. Kisspeptin-10 has a half-life of only a few minutes, so research models use it for acute stimulation tests or repeated administration; continuous exposure desensitises the receptor, a property studied in its own right. Against PT-141, which acts on central melanocortin receptors for arousal, Kisspeptin is the hormone-axis compound: its endpoints are LH, FSH, testosterone and oestrogen.
Specifications
| Compound | Kisspeptin-10 (KP-10) |
| Also known as | Kisspeptin, metastin 45-54, KISS1 45-54, GPR54 agonist |
| CAS number | 374675-21-5 |
| Molecular formula | C63H83N17O14 |
| Molecular weight | 1302.4 g/mol |
| Sequence | YNWNSFGLRF-NH2 (10 amino acids, amidated) |
| Category | Reproductive research |
| Purity | โฅ99% HPLC, batch COA supplied (Janoshik Analytical) |
| Form | Lyophilised powder in a sealed sterile vial |
| Vial size | 10mg |
| Storage (lyophilised) | -20ยฐC, protect from light, avoid freeze-thaw |
| Storage (reconstituted) | 2 to 8ยฐC, use within 28 days |
| Reconstitution | Bacteriostatic water |
Pricing in Australia
$79.99 for 10mg, $8.00 per mg
Kisspeptin-10 is studied in microgram amounts, so a 10mg vial covers a long series of stimulation tests. At 2mL of water, 10 units on a U-100 syringe carries 500mcg.
Reconstitution
Wipe the stopper, add bacteriostatic water slowly down the inside wall, swirl gently until clear, never shake. Refrigerate at 2 to 8ยฐC and use within 28 days.
| Water added | Concentration | Per 10 units on a U-100 syringe |
| 1mL | 10mg/mL | 1mg |
| 2mL | 5mg/mL | 500mcg |
| 3mL | 3.33mg/mL | 333mcg |
The reconstitution calculator runs the maths for any target.
Quality and COA verification
Every batch is tested by Janoshik Analytical: HPLC purity, mass-spec identity against 1302 g/mol, heavy metals and endotoxin. The batch number on the label matches the certificate.
Sydney stock, tracked delivery
No international transit or customs queue. Orders cleared before 12pm AEST leave the same business day; Express Post reaches most metro addresses in one to three business days.
Frequently bought together
$69.99. The melanocortin arousal compound, the other half of reproductive research.
10mL $29.99, 3mL $14.99. Required for reconstitution.
$89.99. The other hypothalamic-pituitary secretagogue.
5 pack $15.99, 10 pack $19.99.
Kisspeptin Australia FAQ
What is Kisspeptin-10?
The ten-amino-acid active fragment of the kisspeptin protein. It binds the KISS1 receptor on hypothalamic GnRH neurons and triggers GnRH, LH and FSH release, sitting at the very top of the reproductive hormone axis.
What is Kisspeptin also known as?
KP-10, metastin 45-54, KISS1 fragment and GPR54 agonist. Kisspeptin-54 is the full-length form; the 10-mer is the shortest fully active fragment and the one used in most research.
How does Kisspeptin work?
It activates GPR54 on GnRH neurons, releasing GnRH into the pituitary portal blood. The pituitary responds with LH and FSH, which in turn drive testosterone and oestrogen. Its half-life is minutes, and continuous exposure desensitises the receptor.
What does the research show?
Rapid LH rises in humans after kisspeptin, restored LH pulsatility in hypothalamic amenorrhoea, kisspeptin-54 as an IVF ovulation trigger that avoids hyperstimulation, and fMRI changes in limbic processing. All from controlled studies of the research compound or its longer form.
Kisspeptin vs PT-141: what is the difference?
Kisspeptin is a hormone-axis compound; the research questions are LH, FSH, testosterone and oestrogen. PT-141 is a central melanocortin compound; the questions are arousal and desire independent of hormone levels.
Can I buy Kisspeptin at Chemist Warehouse in Australia?
No. Kisspeptin is not a registered medicine anywhere and is not stocked by any Australian pharmacy. It is available only as a research-grade lyophilised vial.
How do you reconstitute Kisspeptin-10?
Add bacteriostatic water slowly down the inside wall, swirl gently until clear, never shake, refrigerate at 2 to 8ยฐC and use within 28 days. 2mL gives 5mg/mL, so 10 units carries 500mcg.
Is Kisspeptin available in Australia?
As a research compound, yes: Pure Peptides Australia holds the 10mg vial in Sydney with same-day dispatch. As a medicine, no. As of October 2026 it is not TGA approved.
Where can I buy Kisspeptin in Australia?
From this page. Check out with card, PayID, Osko or bank transfer and the vial leaves Sydney the same business day when payment clears before 12pm AEST, tracked to any Australian address.
What does Kisspeptin cost in Australia?
$79.99 for the 10mg vial, $8.00 per mg. No surcharge on PayID, Osko or bank transfer.
Is Kisspeptin legal in Australia?
Pure Peptides Australia supplies it strictly for lawful in-vitro laboratory research. It is not approved by the TGA for human or veterinary use and is not sold as a medicine, supplement or therapeutic good. Purchasers are responsible for ensuring their use complies with applicable laws.
