Pure Peptides Australia
Melanotan I 10mg โ Research Peptide | Pure Peptides Australia
Melanotan I 10mg โ Research Peptide | Pure Peptides Australia
Not for human, veterinary, diagnostic, or therapeutic use.
Dermal research compound
Melanotan I (10mg): Selective MC1 Receptor Agonist for Pigmentation Research
Melanotan I, also called MT1 and known in pharmaceutical form as afamelanotide, is a 13-amino-acid linear analogue of alpha-melanocyte-stimulating hormone. Two substitutions, norleucine at position 4 and D-phenylalanine at position 7, make it far more potent and longer-lasting than the native hormone while keeping it selective for the melanocortin-1 receptor, the receptor that controls melanin production in skin. That selectivity is the whole story: MT1 is the pigmentation compound, without the appetite and sexual-function activity of Melanotan II. Searched as mt1 peptide australia, melanotan 1 australia, melanotan i, afamelanotide and mt-1.
Pure Peptides Australia holds Melanotan I in Sydney stock as a 10mg lyophilised vial, Janoshik tested before listing. Orders confirmed before 12pm AEST on a business day are dispatched the same day with tracked delivery Australia-wide.
- MT1
- MT-1
- Melanotan 1
- Afamelanotide
- NDP-alpha-MSH
- Scenesse (brand)
- Melanotan one
Melanotan I vs Melanotan II
They share a name and little else in practice. Melanotan I is linear and selective for MC1R, so its research profile is pigmentation. Melanotan II is cyclic and hits MC1R, MC3R, MC4R and MC5R, so it is studied for pigmentation plus appetite and sexual function, and it carries the nausea and flushing that come with MC4R activity. MT1 is the compound for a clean pigmentation model; MT2 for broader melanocortin research. The afamelanotide form of MT1 is the only melanocortin peptide with a marketed implant overseas, for erythropoietic protoporphyria.
Key research areas
Melanogenesis
MC1R activation raises cAMP in melanocytes, driving tyrosinase expression and eumelanin synthesis. The core model for MT1, studied since the 1980s (Hadley and Dorr, Peptides 2006 review).
Photoprotection
Eumelanin absorbs UV and scavenges radicals. Afamelanotide trials in erythropoietic protoporphyria reported increased pain-free sun exposure (Langendonk et al., NEJM 2015).
DNA repair
MC1R signalling is studied for enhancing nucleotide excision repair of UV-induced DNA damage in keratinocytes and melanocytes, independent of pigment.
Vitiligo and polymorphic light eruption
Afamelanotide studied alongside narrowband UVB for repigmentation in vitiligo, and for reducing PLE flares.
Receptor selectivity
In-vitro work characterises MT1's MC1R preference against MT2's broader profile, the basis for its lower off-target activity.
Anti-inflammatory signalling
MC1R is expressed on immune cells; alpha-MSH analogues are studied for damping NF-kB-driven inflammation in skin.
How Melanotan I works
Native alpha-MSH is cleared in minutes. MT1's norleucine and D-phenylalanine substitutions resist enzymatic breakdown and increase receptor affinity roughly a thousand-fold in some assays, so a small amount drives sustained MC1R signalling. The receptor raises intracellular cAMP, which activates the MITF transcription factor and switches melanocytes toward eumelanin, the brown-black photoprotective pigment, rather than pheomelanin. Because MT1 does not meaningfully bind MC4R, it does not produce the appetite suppression, nausea or sexual-function effects that define MT2 research.
Specifications
| Compound | Melanotan I (afamelanotide) |
| Also known as | MT1, MT-1, Melanotan 1, melanotan one, [Nle4, D-Phe7]-alpha-MSH, NDP-alpha-MSH, CUV1647, Scenesse (brand) |
| CAS number | 75921-69-6 |
| Molecular formula | C78H111N21O19 |
| Molecular weight | 1646.9 g/mol |
| Structure | 13 amino acids, linear, Nle4 and D-Phe7 substitutions |
| Category | Dermal research |
| Purity | โฅ99% HPLC, batch COA supplied (Janoshik Analytical) |
| Form | Lyophilised powder in a sealed sterile vial |
| Vial size | 10mg |
| Storage (lyophilised) | -20ยฐC, protect from light, avoid freeze-thaw |
| Storage (reconstituted) | 2 to 8ยฐC, dark, use within 28 days |
| Reconstitution | Bacteriostatic water |
Pricing in Australia
$69.99 for 10mg, $7.00 per mg
A 10mg vial yields ten 1mg aliquots or twenty 0.5mg aliquots. Melanotan I research protocols typically use small, repeated amounts, so one vial covers an extended study. Melanotan II is $79.99 for the same 10mg.
Reconstitution
Wipe the stopper, add bacteriostatic water slowly down the inside wall, swirl gently until clear, never shake. Melanocortin peptides are light-sensitive: keep the reconstituted vial wrapped or in a dark fridge at 2 to 8ยฐC and use within 28 days.
| Water added | Concentration | 0.5mg on a U-100 syringe | 1mg on a U-100 syringe |
| 1mL | 10mg/mL | 5 units | 10 units |
| 2mL | 5mg/mL | 10 units | 20 units |
| 3mL | 3.33mg/mL | 15 units | 30 units |
The reconstitution calculator runs the maths for any target.
Quality and COA verification
Every batch is tested by Janoshik Analytical: HPLC purity, mass-spec identity against 1647 g/mol, heavy metals and endotoxin. The batch number on the label matches the certificate.
Sydney stock, tracked delivery
No international transit or customs queue. Orders cleared before 12pm AEST leave the same business day; Express Post reaches most metro addresses in one to three business days.
Frequently bought together
$79.99. The non-selective comparison compound.
10mL $29.99, 3mL $14.99. Required for reconstitution.
From $89.99. The other dermal research staple.
5 pack $15.99, 10 pack $19.99.
Melanotan I Australia FAQ
What is MT1?
MT1 is Melanotan I, a linear 13-amino-acid analogue of alpha-MSH that is selective for the MC1 receptor. It is the pigmentation research compound, without the appetite and sexual-function activity of Melanotan II. Its pharmaceutical form is called afamelanotide.
What is Melanotan I also known as?
MT1, MT-1, Melanotan 1, melanotan one, NDP-alpha-MSH, [Nle4, D-Phe7]-alpha-MSH, CUV1647 and, as an approved implant overseas, Scenesse.
Melanotan I vs Melanotan II: what is the difference?
MT1 is linear and selective for MC1R, so its research is pigmentation and photoprotection only. MT2 is cyclic and activates MC1R, MC3R, MC4R and MC5R, so it is also studied for appetite and sexual function and carries MC4R side effects such as nausea. Choose MT1 for a clean pigmentation model.
How does Melanotan I work?
It binds MC1R on melanocytes, raising cAMP and activating MITF, which switches melanin production toward eumelanin. Its substitutions make it resistant to breakdown and far more potent than native alpha-MSH.
What does the research show?
Increased eumelanin in melanocyte and animal models; in afamelanotide trials, increased pain-free sun exposure in erythropoietic protoporphyria (NEJM 2015) and repigmentation in vitiligo alongside UVB. MC1R signalling is also studied for enhancing UV-damage DNA repair.
Can I buy Melanotan I at Chemist Warehouse in Australia?
No. Afamelanotide exists overseas as a prescription implant for a rare condition; research-grade Melanotan I is a separate product, not a registered medicine in Australia, and is not stocked by any pharmacy.
How do you reconstitute Melanotan I?
Add bacteriostatic water slowly down the inside wall, swirl gently until clear, never shake. Keep it dark; melanocortin peptides degrade in light. Refrigerate at 2 to 8ยฐC and use within 28 days. 2mL gives 5mg/mL, so 0.5mg is 10 units.
How should Melanotan I be stored?
Lyophilised at -20ยฐC, away from light, without repeated freeze-thaw. Reconstituted in a dark fridge at 2 to 8ยฐC and used within 28 days.
Is Melanotan I available in Australia?
As a research compound, yes: Pure Peptides Australia holds the 10mg vial in Sydney with same-day dispatch. As a medicine, no. As of October 2026 it is not TGA approved.
Where can I buy Melanotan I in Australia?
From this page. Check out with card, PayID, Osko or bank transfer and the vial leaves Sydney the same business day when payment clears before 12pm AEST, tracked to any Australian address.
What does Melanotan I cost in Australia?
$69.99 for the 10mg vial, $7.00 per mg. No surcharge on PayID, Osko or bank transfer.
Is Melanotan I legal in Australia?
Pure Peptides Australia supplies it strictly for lawful in-vitro laboratory research. It is not approved by the TGA for human or veterinary use and is not sold as a medicine, supplement or therapeutic good. Purchasers are responsible for ensuring their use complies with applicable laws.
