Pure Peptides Australia
PT-141 10mg โ Research Peptide | Pure Peptides Australia
PT-141 10mg โ Research Peptide | Pure Peptides Australia
Not for human, veterinary, diagnostic, or therapeutic use.
Reproductive research compound
PT-141 (10mg): Bremelanotide, the Central Melanocortin Arousal Peptide
PT-141, known in pharmaceutical form as bremelanotide, is a cyclic seven-amino-acid melanocortin peptide discovered as a metabolite of Melanotan II. During the University of Arizona tanning trials researchers noticed MT2 produced sexual-function effects; PT-141 is the fragment that kept those effects and lost the pigmentation. It works in the brain, through MC4R, rather than on blood vessels, which sets it apart from every other compound in its field. Searched as pt-141 australia, pt141, bremelanotide australia, pt 141 peptide and vyleesi.
Pure Peptides Australia holds PT-141 in Sydney stock as a 10mg lyophilised vial, Janoshik tested before listing. Orders confirmed before 12pm AEST on a business day are dispatched the same day with tracked delivery Australia-wide.
- PT-141
- PT141
- Bremelanotide
- Vyleesi (brand)
- MC4R agonist
- Bremelanotide acetate
Central, not vascular
PDE5 inhibitors act on blood flow. PT-141 acts on the melanocortin-4 receptor in the hypothalamus and spinal cord, upstream of any vascular response, which is why it is studied for desire and arousal in both sexes rather than for erectile mechanics alone. It was approved overseas in 2019 as bremelanotide for hypoactive sexual desire disorder in premenopausal women, the first melanocortin peptide to reach market for that indication. Kisspeptin is the other reproductive research compound, working on the hormone axis rather than on central arousal circuits.
Key research areas
Female sexual desire
The RECONNECT Phase 3 trials (Kingsberg et al., Obstetrics and Gynecology 2019, n=1,247) reported increased desire and reduced distress versus placebo, the basis of the overseas approval.
Male erectile response
Earlier Phase 2 work reported erectile responses including in PDE5 non-responders (Diamond et al., Journal of Urology 2004).
MC4R pharmacology
The reference central MC4R agonist for arousal circuits, used to map hypothalamic and spinal pathways.
Appetite
MC4R is also the central appetite receptor; PT-141's effect on feeding is studied alongside.
Blood pressure signal
Transient blood pressure rise was the main safety finding in trials, studied as an MC4R-mediated effect.
Comparison with MT2
Parent and metabolite: MT2 hits MC1R for pigmentation plus MC4R; PT-141 keeps MC4R and loses the tan.
How PT-141 works
PT-141 binds MC4R, and to a lesser extent MC3R, in the medial preoptic area of the hypothalamus and in spinal circuits, increasing dopamine release in pathways tied to sexual motivation. Because the effect is upstream and central, it does not depend on nitric oxide or vascular tone. Its half-life is about two to three hours, with effects reported to begin within an hour and persist for several. The main observed side effects in trials, nausea and flushing, are MC4R-related and shared with MT2.
Specifications
| Compound | PT-141 (bremelanotide) |
| Also known as | PT141, PT 141, bremelanotide acetate, Vyleesi (brand), Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| CAS number | 189691-06-3 |
| Molecular formula | C50H68N14O10 |
| Molecular weight | 1025.2 g/mol |
| Structure | 7 amino acids, cyclic (lactam bridge), free C-terminal acid |
| Half-life (published) | Approximately 2.7 hours |
| Category | Reproductive research |
| Purity | โฅ99% HPLC, batch COA supplied (Janoshik Analytical) |
| Form | Lyophilised powder in a sealed sterile vial |
| Vial size | 10mg |
| Storage (lyophilised) | -20ยฐC, protect from light, avoid freeze-thaw |
| Storage (reconstituted) | 2 to 8ยฐC, dark, use within 28 days |
| Reconstitution | Bacteriostatic water |
Pricing in Australia
$69.99 for 10mg, $7.00 per mg
Published PT-141 amounts are in the 0.5 to 2mg range per use, so a 10mg vial covers five to twenty draws. Melanotan II, the parent compound, is $79.99.
Reconstitution
Wipe the stopper, add bacteriostatic water slowly down the inside wall, swirl gently until clear, never shake. Melanocortin peptides are light-sensitive; keep the vial dark. Refrigerate at 2 to 8ยฐC and use within 28 days.
| Water added | Concentration | 1mg on a U-100 syringe | 2mg on a U-100 syringe |
| 2mL | 5mg/mL | 20 units | 40 units |
| 1mL | 10mg/mL | 10 units | 20 units |
The reconstitution calculator runs the maths for any target.
Quality and COA verification
Every batch is tested by Janoshik Analytical: HPLC purity, mass-spec identity against 1025 g/mol, heavy metals and endotoxin. The batch number on the label matches the certificate.
Sydney stock, tracked delivery
No international transit or customs queue. Orders cleared before 12pm AEST leave the same business day; Express Post reaches most metro addresses in one to three business days.
Frequently bought together
$79.99. The parent compound.
$79.99. The hormone-axis arm of reproductive research.
10mL $29.99, 3mL $14.99. Required for reconstitution.
5 pack $15.99, 10 pack $19.99.
PT-141 Australia FAQ
What is PT-141?
A cyclic melanocortin peptide, bremelanotide, discovered as a metabolite of Melanotan II. It acts on MC4R in the brain and is studied for sexual desire and arousal in both sexes. Approved overseas in 2019 as Vyleesi.
PT-141 vs Melanotan II?
MT2 is the parent: it tans through MC1R and has MC4R effects. PT-141 keeps the MC4R arousal effect and loses the pigmentation.
How does PT-141 work?
It binds MC4R in the hypothalamus and spinal cord, raising dopamine in sexual-motivation pathways. The effect is central and upstream of blood flow, unlike PDE5 inhibitors.
What does the research show?
Increased desire and reduced distress in the RECONNECT Phase 3 trials in premenopausal women, and erectile responses in earlier Phase 2 work including PDE5 non-responders. Nausea, flushing and transient blood pressure rise were the main safety findings.
Can I buy PT-141 at Chemist Warehouse in Australia?
No. Bremelanotide is not registered in Australia and research-grade PT-141 is not a pharmacy product. It is available only as a research-grade lyophilised vial.
How do you reconstitute PT-141?
Add bacteriostatic water slowly down the inside wall, swirl gently until clear, never shake, keep it dark, refrigerate at 2 to 8ยฐC and use within 28 days. 2mL gives 5mg/mL, so 1mg is 20 units.
Is PT-141 available in Australia?
As a research compound, yes: Pure Peptides Australia holds the 10mg vial in Sydney with same-day dispatch. As a medicine, no. As of October 2026 bremelanotide is not TGA approved.
Where can I buy PT-141 in Australia?
From this page. Check out with card, PayID, Osko or bank transfer and the vial leaves Sydney the same business day when payment clears before 12pm AEST, tracked to any Australian address.
What does PT-141 cost in Australia?
$69.99 for the 10mg vial, $7.00 per mg. No surcharge on PayID, Osko or bank transfer.
Is PT-141 legal in Australia?
Pure Peptides Australia supplies it strictly for lawful in-vitro laboratory research. It is not approved by the TGA for human or veterinary use and is not sold as a medicine, supplement or therapeutic good. Purchasers are responsible for ensuring their use complies with applicable laws.
