Pure Peptides Australia
AOD-9604 โ Research Peptide | Pure Peptides Australia
AOD-9604 โ Research Peptide | Pure Peptides Australia
Not for human, veterinary, diagnostic, or therapeutic use.
Metabolic research compound
AOD-9604 (5mg): The Growth Hormone Fragment for Fat Metabolism Research
AOD-9604 is a 16-amino-acid fragment of human growth hormone, residues 177 to 191, the C-terminal region that carries GH's effect on fat metabolism, with a tyrosine added to stabilise it. It was developed at Monash University in the 1990s specifically to separate GH's lipolytic activity from its growth and insulin-resistance effects: it acts on fat metabolism without raising IGF-1 or blood glucose. Searched as aod-9604 australia, aod 9604, aod9604 peptide, anti obesity drug 9604 and hgh fragment 176-191.
Pure Peptides Australia holds AOD-9604 in Sydney stock as a 5mg lyophilised vial, Janoshik tested before listing. Orders confirmed before 12pm AEST on a business day are dispatched the same day with tracked delivery Australia-wide.
- AOD-9604
- AOD9604
- HGH fragment 176-191
- Tyr-hGH 177-191
- Anti-obesity drug 9604
An Australian compound
AOD-9604 was developed by Metabolic Pharmaceuticals in Melbourne from Frank Ng's work at Monash on the lipolytic domain of growth hormone. It went through Phase 2 trials in Australia in the early 2000s as an oral obesity candidate, and in 2014 received GRAS status in the United States as a food ingredient after safety review. It is the one compound in the range with an Australian research history, and one of the few with human safety data across several hundred trial participants.
Key research areas
Lipolysis without growth
Stimulates fat breakdown and inhibits lipogenesis in adipocytes without the IGF-1 rise, insulin resistance or cell proliferation of full-length GH (Heffernan et al., Journal of Clinical Endocrinology and Metabolism 2001).
Obesity models
Reduced body weight and fat mass in obese mouse models; modest effects in the 2000s human trials.
Beta-3 adrenergic signalling
Proposed to act through beta-3 adrenergic receptors in fat, the same pathway as adrenaline-driven lipolysis.
Cartilage repair
Studied with hyaluronic acid in osteoarthritis models for cartilage regeneration (Kwon and Park, 2015).
Safety profile
Six clinical trials with no effect on glucose, IGF-1 or GH-related adverse events, the basis of its GRAS status.
Comparison with incretin peptides
Fat-tissue mechanism versus the appetite and gastric mechanism of Retatrutide and Tirzepatide.
How AOD-9604 works
The C-terminal region of GH mimics the way full-length GH switches fat cells toward lipolysis, upregulating beta-3 adrenergic receptors and hormone-sensitive lipase while suppressing the enzymes that build fat. Because the fragment lacks the receptor-binding domains that drive IGF-1 release and cell growth, it produces none of GH's effects on growth, glucose or insulin. Half-life is short, under an hour, so research models use daily administration. Its effect in animal models was independent of food intake, which separates it mechanistically from the GLP-1 class.
Specifications
| Compound | AOD-9604 (Tyr-hGH 177-191) |
| Also known as | AOD9604, anti-obesity drug 9604, HGH fragment 176-191 (with Tyr), lipolytic GH fragment |
| CAS number | 221231-10-3 |
| Molecular formula | C78H123N23O23S2 |
| Molecular weight | 1815.1 g/mol |
| Structure | 16 amino acids, disulfide bridge, N-terminal tyrosine |
| Category | Metabolic research |
| Purity | โฅ99% HPLC, batch COA supplied (Janoshik Analytical) |
| Form | Lyophilised powder in a sealed sterile vial |
| Vial size | 5mg |
| Storage (lyophilised) | -20ยฐC, protect from light, avoid freeze-thaw |
| Storage (reconstituted) | 2 to 8ยฐC, use within 28 days |
| Reconstitution | Bacteriostatic water |
Pricing in Australia
$79.99 for 5mg, $16.00 per mg
AOD-9604 is studied in the 250 to 500mcg range daily, so a 5mg vial covers 10 to 20 days. For the appetite-axis comparison, Retatrutide from $99.99.
Reconstitution
Wipe the stopper, add bacteriostatic water slowly down the inside wall, swirl gently until clear, never shake. Refrigerate at 2 to 8ยฐC and use within 28 days.
| Water added | Concentration | 250mcg on a U-100 syringe | 500mcg on a U-100 syringe |
| 1mL | 5mg/mL | 5 units | 10 units |
| 2mL | 2.5mg/mL | 10 units | 20 units |
The reconstitution calculator runs the maths for any target.
Quality and COA verification
Every batch is tested by Janoshik Analytical: HPLC purity, mass-spec identity against 1815 g/mol, heavy metals and endotoxin. The batch number on the label matches the certificate.
Sydney stock, tracked delivery
No international transit or customs queue. Orders cleared before 12pm AEST leave the same business day; Express Post reaches most metro addresses in one to three business days.
Frequently bought together
$99.99. The NNMT-inhibitor fat metabolism route.
From $99.99. The appetite-axis comparison.
From $99.99. Mitochondrial metabolic signalling.
10mL $29.99, 3mL $14.99. Required for reconstitution.
AOD-9604 Australia FAQ
What is AOD-9604?
A 16-amino-acid fragment of human growth hormone (residues 177 to 191 plus a tyrosine) that carries GH's fat-metabolism activity without its growth or glucose effects. Developed at Monash University in Melbourne.
Is AOD-9604 the same as HGH fragment 176-191?
Effectively yes. AOD-9604 is the stabilised form of the 176-191 fragment with an N-terminal tyrosine; the two names are used interchangeably.
How does AOD-9604 work?
It mimics GH's lipolytic signal in fat cells, upregulating beta-3 adrenergic receptors and hormone-sensitive lipase and suppressing lipogenesis, without the receptor domains that drive IGF-1 release or cell growth.
What does the research show?
Reduced fat mass in obese mouse models, modest effects in 2000s Australian human trials, no effect on glucose or IGF-1 across six clinical studies, GRAS status in the US in 2014, and cartilage repair in osteoarthritis models with hyaluronic acid.
AOD-9604 vs Retatrutide?
Different mechanisms. AOD-9604 acts on fat tissue directly and does not affect appetite. Retatrutide acts on appetite, gastric emptying and energy expenditure through incretin and glucagon receptors, with far larger effects in trials.
Can I buy AOD-9604 at Chemist Warehouse in Australia?
No. AOD-9604 is not a registered medicine in Australia and no pharmacy stocks it. It is available only as a research-grade lyophilised vial.
How do you reconstitute AOD-9604?
Add bacteriostatic water slowly down the inside wall, swirl gently until clear, never shake, refrigerate at 2 to 8ยฐC and use within 28 days. 1mL gives 5mg/mL, so 250mcg is 5 units.
Is AOD-9604 available in Australia?
As a research compound, yes: Pure Peptides Australia holds the 5mg vial in Sydney with same-day dispatch. As a medicine, no. As of October 2026 it is not TGA approved.
Where can I buy AOD-9604 in Australia?
From this page. Check out with card, PayID, Osko or bank transfer and the vial leaves Sydney the same business day when payment clears before 12pm AEST, tracked to any Australian address.
What does AOD-9604 cost in Australia?
$79.99 for the 5mg vial, $16.00 per mg. No surcharge on PayID, Osko or bank transfer.
Is AOD-9604 legal in Australia?
Pure Peptides Australia supplies it strictly for lawful in-vitro laboratory research. It is not approved by the TGA for human or veterinary use and is not sold as a medicine, supplement or therapeutic good. Purchasers are responsible for ensuring their use complies with applicable laws.
