Pure Peptides Australia
Cagrilintide โ Research Peptide | Pure Peptides Australia
Cagrilintide โ Research Peptide | Pure Peptides Australia
Not for human, veterinary, diagnostic, or therapeutic use.
Metabolic research compound
Cagrilintide (10mg): Long-Acting Amylin Analogue for Combination Metabolic Research
Cagrilintide is a lipidated analogue of amylin, the hormone co-secreted with insulin that slows gastric emptying and signals satiety through the brainstem. Developed by Novo Nordisk, it is best known as the amylin half of CagriSema, the combination with semaglutide that reported around 22.7% weight reduction in the REDEFINE-1 trial. Because it acts on amylin and calcitonin receptors rather than incretin receptors, it is the compound researchers pair with the GLP-1 class to study additive mechanisms. Searched as cagrilintide australia, cagrilintide peptide, cagri, cagrisema and amylin analogue.
Pure Peptides Australia holds Cagrilintide in Sydney stock as a 10mg lyophilised vial, Janoshik tested before listing. Orders confirmed before 12pm AEST on a business day are dispatched the same day with tracked delivery Australia-wide.
- Cagrilintide
- Cagri
- NNC0174-0833
- Amylin analogue
- CagriSema component
- Cagrilintide 10mg
The amylin axis, not the incretin axis
Every other metabolic peptide in the range, Retatrutide, Tirzepatide, semaglutide, works through GLP-1 and its relatives. Cagrilintide works through amylin, a separate satiety signal from the pancreas. That independence is why it is studied in combination: in REDEFINE-1 (announced 2025, n=3,417, 68 weeks), CagriSema reported 22.7% weight reduction against 16.1% for semaglutide alone and 11.8% for cagrilintide alone. Its C20 fatty diacid gives a half-life of about a week, matching the once-weekly peptides it is paired with.
Key research areas
Amylin receptor pharmacology
Dual agonism at amylin receptors (calcitonin receptor plus RAMPs) and the calcitonin receptor itself, unlike native amylin.
Combination with GLP-1 agonists
The additive weight reduction of amylin plus incretin signalling, the CagriSema model (Frias et al., Lancet 2023 Phase 2; REDEFINE-1 Phase 3).
Monotherapy
Phase 2 reported 10.8% weight reduction at 26 weeks alone (Lau et al., Lancet 2021), the largest of any amylin analogue.
Gastric emptying and satiety
Brainstem area postrema signalling and slowed gastric emptying, the classic amylin effects.
Lean-mass preservation
Studied for a more favourable fat-to-lean loss ratio than GLP-1 agonists alone.
Pramlintide comparison
Against the first amylin analogue, which needed three daily administrations; cagrilintide is once weekly.
How Cagrilintide works
Native amylin aggregates and has a half-life of minutes. Cagrilintide substitutes the aggregation-prone residues and attaches a C20 fatty diacid that binds albumin, extending its half-life to around seven days. It activates amylin receptors in the area postrema of the brainstem, producing satiety and slowing gastric emptying, and unlike native amylin it also activates the calcitonin receptor directly, which is proposed to explain its stronger effect. Paired with Retatrutide or Tirzepatide, it adds a mechanism those compounds do not touch.
Specifications
| Compound | Cagrilintide (NNC0174-0833) |
| Also known as | Cagri, AM833, cagrilintide peptide, long-acting amylin analogue |
| CAS number | 1415456-99-3 |
| Molecular formula | C194H311N55O56S2 |
| Molecular weight | 4409.0 g/mol |
| Structure | 37-amino-acid amylin analogue, C20 fatty diacid lipidation |
| Half-life (published) | Approximately 7 days |
| Category | Metabolic research |
| Purity | โฅ99% HPLC, batch COA supplied (Janoshik Analytical) |
| Form | Lyophilised powder in a sealed sterile vial |
| Vial size | 10mg |
| Storage (lyophilised) | -20ยฐC, protect from light, avoid freeze-thaw |
| Storage (reconstituted) | 2 to 8ยฐC, use within 28 days |
| Reconstitution | Bacteriostatic water |
Pricing in Australia
$149.99 for 10mg, $15.00 per mg
Trial arms used 2.4mg weekly at the top level, so a 10mg vial covers four weekly aliquots at that amount or ten at 1mg. Combination designs pair it with a Retatrutide 10mg ($159.99) or Tirzepatide 10mg ($119.99).
Reconstitution
Wipe the stopper, add bacteriostatic water slowly down the inside wall, swirl gently until clear, never shake. Refrigerate at 2 to 8ยฐC and use within 28 days.
| Water added | Concentration | 1mg on a U-100 syringe | 2.4mg on a U-100 syringe |
| 2mL | 5mg/mL | 20 units | 48 units |
| 1mL | 10mg/mL | 10 units | 24 units |
The reconstitution calculator runs the maths for any target.
Quality and COA verification
Every batch is tested by Janoshik Analytical: HPLC purity, mass-spec identity against 4409 g/mol, heavy metals and endotoxin. The batch number on the label matches the certificate.
Sydney stock, tracked delivery
No international transit or customs queue. Orders cleared before 12pm AEST leave the same business day; Express Post reaches most metro addresses in one to three business days.
Frequently bought together
$159.99. The triple-agonist combination partner.
$119.99. The dual-agonist combination partner.
10mL $29.99, 3mL $14.99. Required for reconstitution.
5 pack $15.99, 10 pack $19.99.
Cagrilintide Australia FAQ
What is Cagrilintide?
A long-acting lipidated amylin analogue developed by Novo Nordisk, the amylin half of CagriSema. It works through amylin and calcitonin receptors rather than incretin receptors, and is studied in combination with GLP-1 peptides for additive weight reduction.
What is CagriSema?
The combination of cagrilintide with semaglutide. In the REDEFINE-1 Phase 3 trial it reported 22.7% weight reduction at 68 weeks against 16.1% for semaglutide alone and 11.8% for cagrilintide alone.
How does Cagrilintide work?
It activates amylin receptors in the brainstem for satiety and slowed gastric emptying, and unlike native amylin also activates the calcitonin receptor directly. A C20 fatty diacid gives a one-week half-life.
Cagrilintide vs Retatrutide?
Different receptor families. Retatrutide acts on GLP-1, GIP and glucagon receptors; Cagrilintide on amylin and calcitonin receptors. They are combined rather than compared, since neither touches the other's mechanism.
What does the research show?
10.8% weight reduction alone at 26 weeks in Phase 2, 22.7% with semaglutide at 68 weeks in Phase 3, and a proposed lean-mass advantage. All from the sponsor's controlled trials of a pharmaceutical-grade product.
Can I buy Cagrilintide at Chemist Warehouse in Australia?
No. Cagrilintide is not approved anywhere as of October 2026 and no pharmacy stocks it. It is available only as a research-grade lyophilised vial.
How do you reconstitute Cagrilintide?
Add bacteriostatic water slowly down the inside wall, swirl gently until clear, never shake, refrigerate at 2 to 8ยฐC and use within 28 days. 2mL gives 5mg/mL, so 1mg is 20 units.
Is Cagrilintide available in Australia?
As a research compound, yes: Pure Peptides Australia holds the 10mg vial in Sydney with same-day dispatch. As a medicine, no. It is not TGA approved and Novo has not yet filed CagriSema in Australia.
Where can I buy Cagrilintide in Australia?
From this page. Check out with card, PayID, Osko or bank transfer and the vial leaves Sydney the same business day when payment clears before 12pm AEST, tracked to any Australian address.
What does Cagrilintide cost in Australia?
$149.99 for the 10mg vial, $15.00 per mg. No surcharge on PayID, Osko or bank transfer.
Is Cagrilintide legal in Australia?
Pure Peptides Australia supplies it strictly for lawful in-vitro laboratory research. It is not approved by the TGA for human or veterinary use and is not sold as a medicine, supplement or therapeutic good. Purchasers are responsible for ensuring their use complies with applicable laws.
