Pure Peptides Australia
Semax 10mg β Research Peptide | Pure Peptides Australia
Semax 10mg β Research Peptide | Pure Peptides Australia
Not for human, veterinary, diagnostic, or therapeutic use.
Nootropic research compound
Semax (5mg and 10mg): ACTH-Derived Heptapeptide for Cognitive and Neuroprotection Research
Semax is a seven-amino-acid peptide, Met-Glu-His-Phe-Pro-Gly-Pro, built from the 4 to 7 fragment of adrenocorticotropic hormone with a Pro-Gly-Pro tail added to protect it from breakdown. Developed at the Institute of Molecular Genetics in Moscow in the 1980s, it is the most studied of the Russian nootropic peptides and the one with the largest body of published work on BDNF, attention and stroke recovery. Searched as semax australia, semax peptide, se max, semax nasal spray and semax vs selank.
Pure Peptides Australia holds Semax in Sydney stock in 5mg and 10mg vials, Janoshik tested before listing. Orders confirmed before 12pm AEST on a business day are dispatched the same day with tracked delivery Australia-wide.
- Semax
- Se max
- ACTH 4-7 Pro-Gly-Pro
- MEHFPGP
- Russian nootropic peptide
- Semax peptide
Semax vs Selank
The two are always compared and rarely interchangeable. Semax is the stimulating one: its research centres on BDNF, attention, memory consolidation and recovery after ischaemic injury. Selank is the calming one, derived from tuftsin rather than ACTH, with research on anxiety, GABA modulation and stress. Studies that use both do so for the contrast, not because they overlap. The N-Acetyl Semax variant adds an acetyl group for a longer half-life.
Key research areas
BDNF and neurotrophins
Rapid increases in BDNF and TrkB receptor expression in rat hippocampus (Dolotov et al., Journal of Neurochemistry 2006), the mechanism most cited for its cognitive effects.
Attention and memory
Studied for attention, learning and memory consolidation in rodent models and in Russian clinical work on cognitive performance under load.
Ischaemic stroke
Registered in Russia for acute stroke; research examines neuroprotection, reduced infarct volume and gene-expression changes in ischaemic tissue.
Dopamine and serotonin
Reported to modulate striatal dopamine and serotonin turnover, tying it to motivation and mood endpoints.
Optic nerve and retina
Studied in optic nerve atrophy and glaucoma models for retinal ganglion cell survival.
Enkephalin protection
Inhibits enkephalin-degrading enzymes, extending the activity of endogenous opioid peptides involved in stress and pain.
How Semax works
Semax has no dedicated receptor. Its ACTH-derived core interacts with melanocortin receptors in the brain without the hormonal effects of ACTH itself, and the Pro-Gly-Pro tail resists peptidases so the molecule survives long enough to act. Within hours of administration it raises BDNF and NGF expression in the hippocampus and frontal cortex, upregulates TrkB, and shifts the balance of immediate-early genes toward neuroprotection. It also blocks enkephalinases, extending endogenous enkephalin signalling. Half-life is short, which is why intranasal delivery dominates the research literature.
Specifications
| Compound | Semax |
| Also known as | Se max, ACTH (4-7)-Pro-Gly-Pro, Met-Glu-His-Phe-Pro-Gly-Pro, MEHFPGP, Semax peptide |
| CAS number | 80714-61-0 |
| Molecular formula | C37H51N9O10S |
| Molecular weight | 813.9 g/mol |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro (7 amino acids) |
| Category | Nootropic research |
| Purity | β₯99% HPLC, batch COA supplied (Janoshik Analytical) |
| Form | Lyophilised powder in a sealed sterile vial |
| Vial sizes | 5mg, 10mg |
| Storage (lyophilised) | -20Β°C, protect from light, avoid freeze-thaw |
| Storage (reconstituted) | 2 to 8Β°C, use within 28 days |
| Reconstitution | Bacteriostatic water |
Sizes and pricing in Australia
5mg for a short arm, 10mg at a third less per mg
| Vial | Price | Per mg | Yields |
| 5mg | $59.99 | $12.00 | Twenty-five 200mcg draws |
| 10mg | $79.99 | $8.00 | Fifty 200mcg draws |
Semax is studied in microgram amounts, often several times a day in short courses, so a 10mg vial covers a full course with room to spare.
Reconstitution
Wipe the stopper, add bacteriostatic water slowly down the inside wall, swirl gently until clear, never shake. Refrigerate at 2 to 8Β°C and use within 28 days.
| Vial | Water added | Concentration | Per 10 units on a U-100 syringe |
| 5mg | 2mL | 2.5mg/mL | 250mcg |
| 10mg | 2mL | 5mg/mL | 500mcg |
| 10mg | 5mL | 2mg/mL | 200mcg |
The reconstitution calculator runs the maths for any target.
Quality and COA verification
Every batch is tested by Janoshik Analytical: HPLC purity, mass-spec identity against 814 g/mol, heavy metals and endotoxin. The batch number on the label matches the certificate.
Sydney stock, tracked delivery
No international transit or customs queue. Orders cleared before 12pm AEST leave the same business day; Express Post reaches most metro addresses in one to three business days.
Frequently bought together
$79.99. The calming counterpart.
The longer-acting acetylated variant.
$89.99. Delta sleep-inducing peptide for the sleep arm.
10mL $29.99, 3mL $14.99. Required for reconstitution.
Semax Australia FAQ
What is Semax?
A seven-amino-acid peptide derived from ACTH 4-7 with a Pro-Gly-Pro tail, developed in Moscow in the 1980s. It is studied for BDNF expression, attention, memory and neuroprotection after ischaemic injury, and is the most researched of the Russian nootropic peptides.
Semax vs Selank: what is the difference?
Semax is ACTH-derived and stimulating, studied for cognition and BDNF. Selank is tuftsin-derived and calming, studied for anxiety and GABA modulation. They are used together for contrast rather than as substitutes.
Semax vs N-Acetyl Semax?
N-Acetyl Semax adds an acetyl group to the N-terminus, resisting breakdown further and extending activity. Standard Semax is the compound most of the published research used.
How does Semax work?
It raises BDNF and NGF in the hippocampus and cortex within hours, upregulates TrkB, modulates dopamine and serotonin turnover, and blocks enkephalin-degrading enzymes. It has no dedicated receptor; its ACTH core interacts with central melanocortin receptors.
What does the research show?
Increased BDNF and TrkB in rodent hippocampus, improved attention and memory in animal models, neuroprotection and reduced infarct volume in stroke models, and retinal ganglion cell survival in optic nerve models. Most human data come from Russian clinical use.
Can I buy Semax at Chemist Warehouse in Australia?
No. Semax is not a registered medicine in Australia and is not stocked by any pharmacy. It is available only as a research-grade lyophilised vial.
How do you reconstitute Semax?
Add bacteriostatic water slowly down the inside wall, swirl gently until clear, never shake, refrigerate at 2 to 8Β°C and use within 28 days. 2mL into the 10mg gives 5mg/mL, so 10 units carries 500mcg.
Is Semax available in Australia?
As a research compound, yes: Pure Peptides Australia holds 5mg and 10mg vials in Sydney with same-day dispatch. As a medicine, no. As of October 2026 it is not TGA approved.
Where can I buy Semax in Australia?
From this page. Choose a size, check out with card, PayID, Osko or bank transfer, and the vial leaves Sydney the same business day when payment clears before 12pm AEST, tracked to any Australian address.
What does Semax cost in Australia?
$59.99 for 5mg ($12.00 per mg) or $79.99 for 10mg ($8.00 per mg). No surcharge on PayID, Osko or bank transfer.
Is Semax legal in Australia?
Pure Peptides Australia supplies it strictly for lawful in-vitro laboratory research. It is not approved by the TGA for human or veterinary use and is not sold as a medicine, supplement or therapeutic good. Purchasers are responsible for ensuring their use complies with applicable laws.
