Pure Peptides Australia
SLU-PP-332 โ Research Peptide | Pure Peptides Australia
SLU-PP-332 โ Research Peptide | Pure Peptides Australia
Not for human, veterinary, diagnostic, or therapeutic use.
Metabolic research compound
SLU-PP-332 (5mg): ERR Agonist Exercise Mimetic for Endurance and Metabolic Research
SLU-PP-332 is a small-molecule agonist of the oestrogen-related receptors ERR-alpha, beta and gamma, the nuclear receptors that switch on the gene programme muscle runs when it trains for endurance. Developed by Thomas Burris's group at Saint Louis University and Washington University, it is the compound that gave the term exercise mimetic its current meaning: in mice it increased mitochondrial content and oxidative fibres in muscle, lengthened running time and reduced fat mass without any change in food intake or activity. It is not a peptide. Searched as slu-pp-332 australia, slu pp 332, slu-pp-332 peptide, exercise mimetic and err agonist.
Pure Peptides Australia holds SLU-PP-332 in Sydney stock as a 5mg lyophilised vial, Janoshik tested before listing. Orders confirmed before 12pm AEST on a business day are dispatched the same day with tracked delivery Australia-wide.
- SLU-PP-332
- SLU PP 332
- ERR pan-agonist
- Exercise mimetic
- Small molecule, not a peptide
What ERR does
Endurance training raises PGC-1alpha in muscle, which partners with ERR-alpha to switch on hundreds of genes for mitochondrial biogenesis, fatty-acid oxidation and slow-twitch fibre type. SLU-PP-332 activates ERR directly, running that programme without the training. In the 2023 and 2024 papers from Burris's group, treated mice ran up to 70% longer, gained oxidative fibres, and lost fat on a high-fat diet with no change in eating or movement. It is studied alongside MOTS-c, the peptide exercise mimetic, as two routes to the same adaptation.
Key research areas
Endurance capacity
Increased running time and distance in treated mice with more oxidative type IIa fibres (Billon et al., ACS Chemical Biology 2023).
Mitochondrial biogenesis
Raised mitochondrial content and respiratory capacity in skeletal muscle through the ERR-PGC-1alpha axis.
Fat mass and diet-induced obesity
Reduced fat gain on a high-fat diet with unchanged intake, via higher whole-body energy expenditure (Billon et al., Journal of Pharmacology and Experimental Therapeutics 2024).
Cardiac energetics
ERR agonism studied for cardiac mitochondrial function in heart failure models.
Muscle ageing
Studied for preserving oxidative capacity and fibre type in sarcopenia models.
Comparison with MOTS-c
Nuclear receptor agonist versus mitochondrial-derived signalling peptide, both labelled exercise mimetics.
How SLU-PP-332 works
The three ERR isoforms are orphan nuclear receptors with no known natural ligand; they are controlled by coactivators such as PGC-1alpha. SLU-PP-332 binds them directly and stabilises the active conformation, recruiting coactivators and driving transcription of the oxidative-metabolism gene set. Its half-life in mice is short, around one to two hours, and it is orally active in those models. Because it acts at the transcriptional level, its effects on muscle build over days to weeks of repeated exposure rather than acutely.
Specifications
| Compound | SLU-PP-332 |
| Also known as | SLU PP 332, ERR pan-agonist, ERR-alpha agonist, exercise mimetic compound |
| CAS number | 303760-60-3 |
| Molecular formula | C16H13N3O |
| Molecular weight | 263.3 g/mol |
| Category | Metabolic research (small molecule, non-peptide) |
| Purity | โฅ99% HPLC, batch COA supplied (Janoshik Analytical) |
| Form | Lyophilised powder in a sealed sterile vial |
| Vial size | 5mg |
| Storage (lyophilised) | -20ยฐC, protect from light and moisture |
| Storage (reconstituted) | 2 to 8ยฐC, use within 28 days |
| Reconstitution | Poorly water-soluble; dissolve in a small volume of DMSO then dilute into bacteriostatic water |
Pricing in Australia
$149.99 for 5mg, $30.00 per mg
Published mouse models used milligram-per-kilogram amounts, so 5mg covers an in-vitro or small-animal arm. For the peptide exercise mimetic, MOTS-c from $99.99.
Reconstitution
SLU-PP-332 is a hydrophobic small molecule and does not dissolve in water alone. Dissolve the powder in a small volume of DMSO (0.1 to 0.2mL), then dilute into bacteriostatic water to the working concentration, keeping DMSO below 5% of the final volume. Swirl until clear, refrigerate at 2 to 8ยฐC and use within 28 days.
| DMSO | Then water to | Concentration | 250mcg on a U-100 syringe |
| 0.1mL | 2mL total | 2.5mg/mL | 10 units |
| 0.2mL | 5mL total | 1mg/mL | 25 units |
The reconstitution calculator runs the maths for any target once the final volume is set.
Quality and COA verification
Every batch is tested by Janoshik Analytical: HPLC purity, identity against 263 g/mol, heavy metals and endotoxin. The batch number on the label matches the certificate.
Sydney stock, tracked delivery
No international transit or customs queue. Orders cleared before 12pm AEST leave the same business day; Express Post reaches most metro addresses in one to three business days.
Frequently bought together
From $99.99. The peptide exercise mimetic.
$99.99. The other small-molecule metabolic compound.
$129.99. The coenzyme the new mitochondria run on.
10mL $29.99, 3mL $14.99. For the dilution step.
SLU-PP-332 Australia FAQ
What is SLU-PP-332?
A small-molecule agonist of the ERR nuclear receptors that switch on muscle's endurance-training gene programme. In mice it increased mitochondria and oxidative fibres, lengthened running time and reduced fat mass without changes in intake or activity. It is not a peptide.
How does SLU-PP-332 work?
It binds ERR-alpha, beta and gamma directly, stabilising their active form and driving transcription of mitochondrial biogenesis and fatty-acid oxidation genes, the same programme PGC-1alpha activates after endurance exercise.
What does the research show?
Up to 70% longer running time, more type IIa oxidative fibres and higher mitochondrial content in treated mice, and reduced fat gain on a high-fat diet with unchanged eating. All preclinical, from the Burris group's 2023 and 2024 papers.
SLU-PP-332 vs MOTS-c?
Both are called exercise mimetics. SLU-PP-332 is a nuclear receptor agonist acting on gene transcription; MOTS-c is a mitochondrial-derived peptide acting through AMPK. They are studied together as two routes to the same adaptation.
Why DMSO?
SLU-PP-332 is hydrophobic and will not dissolve in water alone. A small volume of DMSO dissolves it, and it is then diluted into bacteriostatic water, keeping DMSO under 5% of the final volume.
Can I buy SLU-PP-332 at Chemist Warehouse in Australia?
No. SLU-PP-332 is not a registered medicine anywhere and no pharmacy stocks it. It is available only as a research-grade lyophilised vial.
Is SLU-PP-332 available in Australia?
As a research compound, yes: Pure Peptides Australia holds the 5mg vial in Sydney with same-day dispatch. As a medicine, no. As of October 2026 it is not TGA approved.
Where can I buy SLU-PP-332 in Australia?
From this page. Check out with card, PayID, Osko or bank transfer and the vial leaves Sydney the same business day when payment clears before 12pm AEST, tracked to any Australian address.
What does SLU-PP-332 cost in Australia?
$149.99 for the 5mg vial, $30.00 per mg. No surcharge on PayID, Osko or bank transfer.
Is SLU-PP-332 legal in Australia?
Pure Peptides Australia supplies it strictly for lawful in-vitro laboratory research. It is not approved by the TGA for human or veterinary use and is not sold as a medicine, supplement or therapeutic good. Purchasers are responsible for ensuring their use complies with applicable laws.
