Pure Peptides Australia
5-amino-1-mq โ Research Peptide | Pure Peptides Australia
5-amino-1-mq โ Research Peptide | Pure Peptides Australia
Not for human, veterinary, diagnostic, or therapeutic use.
Metabolic research compound
5-Amino-1MQ (5mg): NNMT Inhibitor for Fat Metabolism and Muscle Research
5-Amino-1MQ is not a peptide but a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that is overexpressed in fat tissue during obesity and that drains the cell's supply of NAD+ and S-adenosylmethionine. Blocking it raises NAD+, boosts cellular energy expenditure and, in the University of Texas work that put it on the map, shrank fat cells and reversed diet-induced obesity in mice. It is stocked alongside the peptides because it is studied in the same metabolic and longevity models. Searched as 5-amino-1mq australia, 5 amino 1mq, nnmt inhibitor, 5-amino-1-methylquinolinium and 5 amino 1 mq peptide.
Pure Peptides Australia holds 5-Amino-1MQ in Sydney stock as a 5mg lyophilised vial, Janoshik tested before listing. Orders confirmed before 12pm AEST on a business day are dispatched the same day with tracked delivery Australia-wide.
- 5-Amino-1MQ
- 5-amino-1-methylquinolinium
- NNMT inhibitor
- 5-A-1MQ
- Small molecule, not a peptide
Why NNMT
NNMT transfers a methyl group from S-adenosylmethionine to nicotinamide, producing 1-methylnicotinamide and consuming both a methyl donor and the NAD+ precursor in one step. In obese fat tissue NNMT is many times more active than in lean tissue, which lowers NAD+ and SAM, slows fat oxidation and shifts adipocytes toward storage. 5-Amino-1MQ blocks the enzyme selectively and cell-permeably; in the 2018 Biochemical Pharmacology study from Neelakantan and colleagues it reduced adipocyte size and white fat mass in diet-induced obese mice without changing food intake.
Key research areas
Adipocyte metabolism
Reduced lipogenesis, smaller fat cells and lower white adipose mass in diet-induced obesity models (Neelakantan et al., 2018).
NAD+ and SAM levels
Raises intracellular NAD+ and SAM by blocking their consumption, linking it to sirtuin and methylation research.
Muscle stem cells
NNMT inhibition activated muscle satellite cells and improved regeneration in aged mice (Neelakantan et al., Journal of Cachexia, Sarcopenia and Muscle 2019).
Insulin sensitivity
Improved glucose handling alongside fat loss in obese mouse models.
Cancer metabolism
NNMT overexpression in several tumour types; inhibitors studied for effects on tumour cell metabolism.
Comparison with NAD+ supply
Raising NAD+ by blocking its consumption versus supplying it directly, studied alongside NAD+ and precursors.
How 5-Amino-1MQ works
It is a quinolinium compound that mimics nicotinamide and occupies NNMT's substrate site, competitively blocking methylation. With the enzyme inhibited, nicotinamide feeds the NAD+ salvage pathway instead of being methylated away, SAM is preserved for other methylation reactions, and the adipocyte shifts from lipogenesis toward oxidation. Unlike the GLP-1 peptides it does not act on appetite; its effect in animal models was on fat cell metabolism at unchanged intake. It is orally active in those models, which is unusual in a range dominated by injectable peptides.
Specifications
| Compound | 5-Amino-1-methylquinolinium (5-Amino-1MQ) |
| Also known as | 5-A-1MQ, 5 amino 1mq, NNMT inhibitor, 5-amino-1-methylquinolin-1-ium |
| CAS number | 42464-96-0 |
| Molecular formula | C10H11N2+ (cation; supplied as a salt) |
| Molecular weight | 159.2 g/mol (cation) |
| Category | Metabolic research (small molecule, non-peptide) |
| Purity | โฅ99% HPLC, batch COA supplied (Janoshik Analytical) |
| Form | Lyophilised powder in a sealed sterile vial |
| Vial size | 5mg |
| Storage (lyophilised) | -20ยฐC, protect from light and moisture |
| Storage (reconstituted) | 2 to 8ยฐC, use within 28 days |
| Reconstitution | Bacteriostatic water; water-soluble |
Pricing in Australia
$99.99 for 5mg, $20.00 per mg
Published mouse models used milligram-per-kilogram amounts, so 5mg covers a short in-vitro or small-animal arm. Pair with NAD+ ($129.99) to compare blocking NAD+ consumption against supplying it.
Reconstitution
5-Amino-1MQ is a small, water-soluble salt and dissolves readily. Wipe the stopper, add bacteriostatic water, swirl until clear. Refrigerate at 2 to 8ยฐC and use within 28 days.
| Water added | Concentration | 500mcg on a U-100 syringe | 1mg on a U-100 syringe |
| 1mL | 5mg/mL | 10 units | 20 units |
| 2.5mL | 2mg/mL | 25 units | 50 units |
The reconstitution calculator runs the maths for any target.
Quality and COA verification
Every batch is tested by Janoshik Analytical: HPLC purity, identity against 159 g/mol, heavy metals and endotoxin. The batch number on the label matches the certificate.
Sydney stock, tracked delivery
No international transit or customs queue. Orders cleared before 12pm AEST leave the same business day; Express Post reaches most metro addresses in one to three business days.
Frequently bought together
$129.99. Direct NAD+ supply for comparison.
From $99.99. The appetite-axis metabolic peptide.
From $99.99. Mitochondrial metabolic signalling.
$79.99. The GH-fragment fat metabolism peptide.
5-Amino-1MQ Australia FAQ
What is 5-Amino-1MQ?
A small-molecule inhibitor of the enzyme NNMT, which is overactive in obese fat tissue and drains NAD+ and SAM. Blocking it raised NAD+, shrank fat cells and reversed diet-induced obesity in mouse models. It is not a peptide.
How does 5-Amino-1MQ work?
It occupies NNMT's substrate site so nicotinamide feeds the NAD+ salvage pathway instead of being methylated away. Higher NAD+ and preserved SAM shift adipocytes from storage toward oxidation, without changing food intake in animal models.
What does the research show?
Reduced adipocyte size and white fat mass with improved glucose handling in obese mice (2018), and activated muscle stem cells with improved regeneration in aged mice (2019). All preclinical.
5-Amino-1MQ vs NAD+?
Two routes to the same pool: 5-Amino-1MQ stops NAD+ being consumed by NNMT; NAD+ supplies it directly. They are studied in comparison and in combination.
Is it a peptide?
No. It is a quinolinium small molecule, stocked with the peptides because it is studied in the same metabolic and longevity models and handled the same way.
Can I buy 5-Amino-1MQ at Chemist Warehouse in Australia?
No. It is not a registered medicine and no Australian pharmacy stocks it. It is available only as a research-grade lyophilised vial.
How do you reconstitute 5-Amino-1MQ?
Add bacteriostatic water, swirl until clear, refrigerate at 2 to 8ยฐC and use within 28 days. It dissolves readily. 1mL gives 5mg/mL, so 500mcg is 10 units.
Is 5-Amino-1MQ available in Australia?
As a research compound, yes: Pure Peptides Australia holds the 5mg vial in Sydney with same-day dispatch. As a medicine, no. As of October 2026 it is not TGA approved.
Where can I buy 5-Amino-1MQ in Australia?
From this page. Check out with card, PayID, Osko or bank transfer and the vial leaves Sydney the same business day when payment clears before 12pm AEST, tracked to any Australian address.
What does 5-Amino-1MQ cost in Australia?
$99.99 for the 5mg vial, $20.00 per mg. No surcharge on PayID, Osko or bank transfer.
Is 5-Amino-1MQ legal in Australia?
Pure Peptides Australia supplies it strictly for lawful in-vitro laboratory research. It is not approved by the TGA for human or veterinary use and is not sold as a medicine, supplement or therapeutic good. Purchasers are responsible for ensuring their use complies with applicable laws.
