Pure Peptides Australia
Epitalon β Research Peptide | Pure Peptides Australia
Epitalon β Research Peptide | Pure Peptides Australia
Not for human, veterinary, diagnostic, or therapeutic use.
Longevity research compound
Epitalon (10mg and 50mg): Telomerase-Activating Tetrapeptide for Ageing Research
Epitalon, also spelled epithalon and epithalone, is a four-amino-acid peptide, Ala-Glu-Asp-Gly, developed by Vladimir Khavinson at the St Petersburg Institute of Bioregulation and Gerontology as a synthetic version of the active fraction of epithalamin, a pineal gland extract. It is the peptide most closely tied to telomere research: in cultured human cells it reactivates telomerase and extends the number of divisions a cell can make. Searched as epitalon australia, epithalon, epitalon peptide australia and epithalamin.
Pure Peptides Australia holds Epitalon in Sydney stock in 10mg and 50mg vials, Janoshik tested before listing. Orders confirmed before 12pm AEST on a business day are dispatched the same day with tracked delivery Australia-wide.
- Epitalon
- Epithalon
- Epithalone
- Epithalamin (parent extract)
- AEDG peptide
- Khavinson peptide
Why a tetrapeptide is studied for ageing
Telomeres cap the ends of chromosomes and shorten with every cell division; when they run out, the cell stops dividing. Telomerase rebuilds them but is switched off in most adult somatic cells. Khavinson's group reported that Epitalon switches it back on in human fibroblasts, letting cells pass the Hayflick limit (Khavinson et al., Bulletin of Experimental Biology and Medicine 2003). That single observation put a four-amino-acid molecule at the centre of longevity research, alongside its effects on melatonin rhythm and pineal function.
Key research areas
Telomerase and telomeres
Reactivation of telomerase and telomere elongation in cultured human somatic cells, with cells dividing beyond their normal limit.
Circadian and melatonin
Studied for restoring night-time melatonin secretion and circadian rhythm in aged animal models and older subjects.
Lifespan studies
Long-term rodent and Drosophila studies from the Khavinson group reported increased mean lifespan and reduced tumour incidence.
Gene expression
Studied for binding directly to DNA and modulating expression of genes involved in cell proliferation and differentiation.
Antioxidant activity
Reported to increase superoxide dismutase and reduce lipid peroxidation in aged tissue.
Retinal research
Studied for retinal cell preservation in retinitis pigmentosa models, one of the earlier lines of Epitalon work.
How Epitalon works
Two mechanisms are proposed. The first is direct: the short, charged peptide enters the nucleus and binds DNA at specific sequences, upregulating telomerase reverse transcriptase and other proliferation genes. The second is neuroendocrine: it acts on the pineal gland to normalise melatonin output, which in turn resets circadian control of hormones and immune function. Its half-life in circulation is short, so published models use courses of repeated administration two or three times a year rather than continuous exposure. Alongside NAD+ and MOTS-c, it is one of three compounds most often combined in longevity research designs, each acting on a different ageing pathway.
Specifications
| Compound | Epitalon (Epithalon) |
| Also known as | Epithalon, epithalone, AEDG, Ala-Glu-Asp-Gly, epithalamin (parent extract), Khavinson peptide |
| CAS number | 307297-39-8 |
| Molecular formula | C14H22N4O9 |
| Molecular weight | 390.3 g/mol |
| Sequence | Ala-Glu-Asp-Gly (4 amino acids) |
| Category | Longevity research |
| Purity | β₯99% HPLC, batch COA supplied (Janoshik Analytical) |
| Form | Lyophilised powder in a sealed sterile vial |
| Vial sizes | 10mg, 50mg |
| Storage (lyophilised) | -20Β°C, protect from light, avoid freeze-thaw |
| Storage (reconstituted) | 2 to 8Β°C, use within 28 days |
| Reconstitution | Bacteriostatic water |
Sizes and pricing in Australia
10mg for a single course, 50mg for the year
| Vial | Price | Per mg | Suits |
| 10mg | $79.99 | $8.00 | One 10 to 20 day course |
| 50mg | $199.99 | $4.00 | Multiple courses across a year, half the per-mg cost |
Published Epitalon models use short courses of a few milligrams per day repeated a few times a year, so the 50mg vial covers a full year's design for one arm.
Reconstitution
Wipe the stopper, add bacteriostatic water slowly down the inside wall, swirl gently until clear, never shake. Refrigerate at 2 to 8Β°C and use within 28 days.
| Vial | Water added | Concentration | 1mg on a U-100 syringe |
| 10mg | 2mL | 5mg/mL | 20 units |
| 50mg | 2.5mL | 20mg/mL | 5 units |
| 50mg | 5mL | 10mg/mL | 10 units |
The reconstitution calculator runs the maths for any target.
Quality and COA verification
Every batch is tested by Janoshik Analytical: HPLC purity, mass-spec identity against 390 g/mol, heavy metals and endotoxin. The batch number on the label matches the certificate.
Sydney stock, tracked delivery
No international transit or customs queue. Orders cleared before 12pm AEST leave the same business day; Express Post reaches most metro addresses in one to three business days.
Frequently bought together
$129.99. The energy-metabolism half of longevity research.
From $99.99. The mitochondrial signalling peptide.
10mL $29.99, 3mL $14.99. Required for reconstitution.
$79.99. Mitochondrial membrane protection.
Epitalon Australia FAQ
What is Epitalon?
A four-amino-acid peptide, Ala-Glu-Asp-Gly, synthesised as the active fraction of the pineal extract epithalamin. It is studied for telomerase activation, telomere length, melatonin rhythm and lifespan in cell and animal models.
Epitalon or Epithalon?
Same compound. Epitalon is the common English spelling; Epithalon and Epithalone appear in the Russian-origin literature. Epithalamin is the natural pineal extract it was derived from.
How does Epitalon work?
It is reported to bind DNA directly and upregulate telomerase reverse transcriptase, and to act on the pineal gland to normalise melatonin output and circadian rhythm.
What does the research show?
Telomerase reactivation and telomere elongation in cultured human fibroblasts, restored melatonin rhythm in aged animals, and increased mean lifespan with lower tumour incidence in long-term rodent studies from the Khavinson group. Independent replication is limited.
Epitalon vs NAD+ vs MOTS-c?
Three different ageing pathways: Epitalon for telomeres and circadian control, NAD+ for cellular energy and sirtuins, MOTS-c for mitochondrial signalling. Longevity research designs usually pick one from each rather than several from one.
Can I buy Epitalon at Chemist Warehouse in Australia?
No. Epitalon is not a registered medicine and no Australian pharmacy stocks it. It is available only as a research-grade lyophilised vial.
How do you reconstitute Epitalon?
Add bacteriostatic water slowly down the inside wall, swirl gently until clear, never shake, refrigerate at 2 to 8Β°C and use within 28 days. 2mL into the 10mg gives 5mg/mL, so 1mg is 20 units on a U-100 syringe.
10mg or 50mg?
10mg covers one short course. 50mg covers multiple courses across a year at half the per-mg cost, which suits the way published Epitalon models are structured.
Is Epitalon available in Australia?
As a research compound, yes: Pure Peptides Australia holds 10mg and 50mg vials in Sydney with same-day dispatch. As a medicine, no. As of October 2026 it is not TGA approved.
Where can I buy Epitalon in Australia?
From this page. Choose a size, check out with card, PayID, Osko or bank transfer, and the vial leaves Sydney the same business day when payment clears before 12pm AEST, tracked to any Australian address.
What does Epitalon cost in Australia?
$79.99 for 10mg ($8.00 per mg) or $199.99 for 50mg ($4.00 per mg). No surcharge on PayID, Osko or bank transfer.
Is Epitalon legal in Australia?
Pure Peptides Australia supplies it strictly for lawful in-vitro laboratory research. It is not approved by the TGA for human or veterinary use and is not sold as a medicine, supplement or therapeutic good. Purchasers are responsible for ensuring their use complies with applicable laws.
