Pure Peptides Australia
SS-31 โ Research Peptide | Pure Peptides Australia
SS-31 โ Research Peptide | Pure Peptides Australia
Not for human, veterinary, diagnostic, or therapeutic use.
Mitochondrial research compound
SS-31 (10mg): Elamipretide, the Cardiolipin-Binding Mitochondrial Peptide
SS-31, known in pharmaceutical development as elamipretide, is a four-amino-acid peptide from the Szeto-Schiller series that concentrates in the inner mitochondrial membrane and binds cardiolipin, the lipid that holds the electron transport chain together. By stabilising cardiolipin it is studied for restoring ATP production and reducing oxidative stress in ageing and injured mitochondria, the direct structural counterpart to MOTS-c's signalling role. Searched as ss-31 australia, ss31 peptide, elamipretide australia, bendavia and mitochondrial peptide.
Pure Peptides Australia holds SS-31 in Sydney stock as a 10mg lyophilised vial, Janoshik tested before listing. Orders confirmed before 12pm AEST on a business day are dispatched the same day with tracked delivery Australia-wide.
- SS-31
- SS31
- Elamipretide
- Bendavia
- MTP-131
- Szeto-Schiller peptide
Why cardiolipin
Cardiolipin is found almost nowhere in the cell except the inner mitochondrial membrane, where it anchors the respiratory complexes and cytochrome c. With age and oxidative damage cardiolipin peroxidises, the complexes come apart, electrons leak and ATP output falls. SS-31 carries alternating aromatic and basic residues that let it cross membranes and bind cardiolipin selectively, restoring the membrane's structure. It is one of the few compounds with a mechanism that targets the mitochondrion itself rather than a signalling pathway around it, which is why it went into Phase 3 for mitochondrial myopathy and Barth syndrome.
Key research areas
Cardiolipin and ATP
Restored respiratory chain efficiency and ATP synthesis in aged and damaged mitochondria (Szeto, British Journal of Pharmacology 2014).
Primary mitochondrial disease
Phase 2 and 3 trials of elamipretide in mitochondrial myopathy and Barth syndrome (TAZPOWER), the first clinical programme for a mitochondria-targeted peptide.
Ischaemia-reperfusion
Reduced infarct size and reperfusion injury in cardiac and renal models, one of the earliest SS-31 findings.
Heart failure
Studied for cardiac energetics in heart failure with reduced and preserved ejection fraction.
Skeletal muscle ageing
Restored mitochondrial function and exercise capacity in aged mice within hours of administration (Siegel et al., Aging Cell 2013).
Retina and kidney
Studied in dry age-related macular degeneration and diabetic kidney models for tissue-level mitochondrial protection.
How SS-31 works
SS-31 is cell-permeable and accumulates in the inner mitochondrial membrane a thousand-fold over its concentration outside the cell, independent of membrane potential. Its electrostatic and hydrophobic interactions with cardiolipin prevent cardiolipin peroxidation, keep cytochrome c in its electron-carrier configuration rather than its peroxidase configuration, and hold the respiratory supercomplexes together. The result in research models is higher ATP output, lower reactive oxygen species and less mitochondrial swelling. Against MOTS-c, which tells the cell how to respond to mitochondrial stress, SS-31 fixes the mitochondrion directly; the two are often combined for that reason. Half-life is short, in the order of hours.
Specifications
| Compound | SS-31 (elamipretide) |
| Also known as | SS31, elamipretide, Bendavia, MTP-131, D-Arg-Dmt-Lys-Phe-NH2 |
| CAS number | 736992-21-5 |
| Molecular formula | C32H49N9O5 |
| Molecular weight | 639.8 g/mol |
| Sequence | D-Arg-2',6'-dimethyltyrosine-Lys-Phe-NH2 (4 amino acids) |
| Category | Longevity and mitochondrial research |
| Purity | โฅ99% HPLC, batch COA supplied (Janoshik Analytical) |
| Form | Lyophilised powder in a sealed sterile vial |
| Vial size | 10mg |
| Storage (lyophilised) | -20ยฐC, protect from light, avoid freeze-thaw |
| Storage (reconstituted) | 2 to 8ยฐC, use within 28 days |
| Reconstitution | Bacteriostatic water |
Pricing in Australia
$79.99 for 10mg, $8.00 per mg
SS-31 research models use repeated daily administration in the low-milligram range, so a 10mg vial covers a short arm; longer designs pair two vials. Combine with MOTS-c ($99.99) for a structure-plus-signalling mitochondrial design.
Reconstitution
Wipe the stopper, add bacteriostatic water slowly down the inside wall, swirl gently until clear, never shake. Refrigerate at 2 to 8ยฐC and use within 28 days.
| Water added | Concentration | 1mg on a U-100 syringe | 2mg on a U-100 syringe |
| 2mL | 5mg/mL | 20 units | 40 units |
| 1mL | 10mg/mL | 10 units | 20 units |
The reconstitution calculator runs the maths for any target.
Quality and COA verification
Every batch is tested by Janoshik Analytical: HPLC purity, mass-spec identity against 640 g/mol, heavy metals and endotoxin. The batch number on the label matches the certificate.
Sydney stock, tracked delivery
No international transit or customs queue. Orders cleared before 12pm AEST leave the same business day; Express Post reaches most metro addresses in one to three business days.
Frequently bought together
From $99.99. The mitochondrial signalling peptide.
$129.99. The coenzyme the restored chain runs on.
From $79.99. The telomere arm of longevity research.
10mL $29.99, 3mL $14.99. Required for reconstitution.
SS-31 Australia FAQ
What is SS-31?
A four-amino-acid peptide, elamipretide in pharmaceutical development, that concentrates in the inner mitochondrial membrane and binds cardiolipin. It is studied for restoring ATP output and reducing oxidative stress in ageing and injured mitochondria.
Is SS-31 the same as elamipretide?
Yes. SS-31 is the research designation from the Szeto-Schiller series; elamipretide, Bendavia and MTP-131 are the development names for the same molecule.
How does SS-31 work?
It binds cardiolipin in the inner mitochondrial membrane, preventing its peroxidation, keeping cytochrome c as an electron carrier and holding the respiratory complexes together. ATP rises, reactive oxygen species fall.
SS-31 vs MOTS-c?
SS-31 stabilises the mitochondrion's structure directly. MOTS-c is a signalling peptide that tells the cell how to respond to mitochondrial stress. They act on different layers and are often studied together.
What does the research show?
Restored mitochondrial function and exercise capacity in aged mice within hours, reduced ischaemia-reperfusion injury in cardiac and renal models, and Phase 2 and 3 clinical trials in mitochondrial myopathy and Barth syndrome.
Can I buy SS-31 at Chemist Warehouse in Australia?
No. Elamipretide is not registered in Australia and research-grade SS-31 is not a pharmacy product. It is available only as a research-grade lyophilised vial.
How do you reconstitute SS-31?
Add bacteriostatic water slowly down the inside wall, swirl gently until clear, never shake, refrigerate at 2 to 8ยฐC and use within 28 days. 2mL gives 5mg/mL, so 1mg is 20 units.
Is SS-31 available in Australia?
As a research compound, yes: Pure Peptides Australia holds the 10mg vial in Sydney with same-day dispatch. As a medicine, no. As of October 2026 it is not TGA approved.
Where can I buy SS-31 in Australia?
From this page. Check out with card, PayID, Osko or bank transfer and the vial leaves Sydney the same business day when payment clears before 12pm AEST, tracked to any Australian address.
What does SS-31 cost in Australia?
$79.99 for the 10mg vial, $8.00 per mg. No surcharge on PayID, Osko or bank transfer.
Is SS-31 legal in Australia?
Pure Peptides Australia supplies it strictly for lawful in-vitro laboratory research. It is not approved by the TGA for human or veterinary use and is not sold as a medicine, supplement or therapeutic good. Purchasers are responsible for ensuring their use complies with applicable laws.
